Model Organisms as a Guide to Mammalian Aging
نویسندگان
چکیده
منابع مشابه
Invertebrates as model organisms for research on aging biology
Invertebrate model systems, such as nematodes and fruit flies, have provided valuable information about the genetics and cellular biology involved in aging. However, limitations of these simple, genetically tractable organisms suggest the need for other model systems, some of them invertebrate, to facilitate further advances in the understanding of mechanisms of aging and longevity in mammals, ...
متن کاملReproductive aging: insights from model organisms.
Aging was once thought to be the result of a general deterioration of tissues as opposed to their being under regulatory control. However, investigations in a number of model organisms have illustrated that aspects of aging are controlled by genetic mechanisms and are potentially manipulable, suggesting the possibility of treatment for age-related disorders. Reproductive decline is one aspect o...
متن کاملLentiviral vectors as tools to understand central nervous system biology in mammalian model organisms
Lentiviruses have been extensively used as gene delivery vectors since the mid-1990s. Usually derived from the human immunodeficiency virus genome, they mediate efficient gene transfer to non-dividing cells, including neurons and glia in the adult mammalian brain. In addition, integration of the recombinant lentiviral construct into the host genome provides permanent expression, including the p...
متن کاملDetermination of Incisal Point as Anterior Guide to Transfer Maxillary Casts to Articulator: A Pilot Study
Objectives Despite the importance to use face-bow record for transferring maxillary cast to articulator some dentists use average points to avoid the time taken and ease of use. The location of incisal point could help to set the maxillary cast or denture in an appropriate position in mounting stage. This study was designed to determine the incisal point location in ante...
متن کاملIlluminating the Undergraduate Behavioral Neuroscience Laboratory: A Guide for the in vivo Application of Optogenetics in Mammalian Model Organisms.
Optogenetics is a technology that is growing rapidly in neuroscience, establishing itself as a fundamental investigative tool. As this tool is increasingly utilized across the neuroscience community and is one of the primary research techniques being presented at neuroscience conferences and in journals, we believe that it is important that this technology is introduced into the undergraduate n...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Developmental Cell
سال: 2002
ISSN: 1534-5807
DOI: 10.1016/s1534-5807(01)00098-3